The Resource Anticancer agents from natural products, edited by Gordon M. Cragg, David G.I. Kingston, and David J. Newman

Anticancer agents from natural products, edited by Gordon M. Cragg, David G.I. Kingston, and David J. Newman

Anticancer agents from natural products
Anticancer agents from natural products
Statement of responsibility
edited by Gordon M. Cragg, David G.I. Kingston, and David J. Newman
  • "The search for new lead compounds is a crucial element of modern pharmaceutical research. Natural products provided the only source of pharmaceuticals for thousands of years, and natural products have made enormous contributions to human health through compounds such as quinine, morphine, aspirin (a natural product analog), digitoxin, and many others. The potential of natural products as anticancer agents was recognized in the 1950's by the U.S. National Cancer Institute (NCI) under the leadership of the late Dr. Jonathan Hartwell, and the NCI has since made major contributions to the discovery of new naturally occurring anticancer agents through its contract and grant support, including an important program of plant and marine collections. Many, although not all, of the compound classes described in the following pages owe their origin in whole or in part to NCI support. In spite of the success of the natural products approach to anticancer drug discovery, as exemplified by the following chapters, in recent years their importance as a source of molecular diversity for drug discovery research and development has been overshadowed by newer chemical approaches currently in favor. These approaches include chemical ones which make heavy use of combinatorial chemistry, and biological ones such as manipulation of biosynthetic pathways of microbial metabolites through combinatorial biosynthetic techniques. It is thus worthwhile to review briefly the major reasons why natural products are so important. First, there is a strong biological and ecological rationale for plants and marine invertebrates to produce novel bioactive secondary metabolites"--Provided by publisher
  • "This book covers clinically used anticancer agents that are either natural products or are clearly derived from natural product leads. The second edition includes drugs that are currently in development. In addition, the text emphasizes the applications of synthetic and medicinal chemistry to the preparation of analogs with enhanced activities. Contributors also address the potential of novel drug discovery through the use of genome mining as well as the status of advanced development candidates. For each compound of class of compounds, the text provides information on the history, structure, mechanism of action, development, synthesis, medicinal chemistry, and clinical applications"--Provided by publisher
Cataloging source
Dewey number
  • illustrations
  • plates
index present
LC call number
LC item number
A562 2012
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Anticancer agents from natural products, edited by Gordon M. Cragg, David G.I. Kingston, and David J. Newman
Bibliography note
Includes bibliographical references and index
  • net
Carrier category
online resource
Carrier category code
Carrier MARC source
Content category
Content type code
Content type MARC source
Ch. 1. Introduction / Gordon M. Cragg, David G.I. Kingston, and David J. Newman -- ch. 2. Camptothecin and its analogs / Nicolas J. Rahier, Craig J. Thomas, and Sidney M. Hecht -- ch. 3. The discovery and development of the combretastatins / Kevin G. Pinney [and others] -- ch. 4. Homoharringtonine and related compounds / Hideji Itokawa, Yukio Hitotsuyanagi, and Kuo-Hsiung Lee -- ch. 5. Podophyllotoxins and analogs / Kuo-Hsiung Lee and Zhiyan Xiao -- ch. 6. Taxol and its analogs / David G.I. Kingston -- ch. 7. The vinca alkaloids / Fanny Roussi, Françoise Guéritte, and Jacques Fahy -- ch. 8. The bryostatins / David J. Newman -- ch. 9. The isolation, characterization, and development of a novel class of potent antimitotic macrocyclic depsipeptides : the cryptophycins / Rima S. Al-awar and Chuan Shih -- ch. 10. Chemistry and biology of the discodermolides, potent mitotic spindle poisons / Sarath P. Gunasekera and Amy E. Wright -- ch. 11. The dolastatins : novel antitumor agents from Dolabella auricularia / Erik Flahive and Jayaram Srirangam -- ch. 12. Ecteinascidin-743 (Yondelis), Aplidin, and Irvalec / Carmen Cuevas [and others] -- ch. 13. Discovery of E7389, a fully synthetic macrocyclic ketone analog of halichondrin B / Melvin J. Yu, Yoshito Kishi, and Bruce A. Littlefield
Control code
2nd ed
1 online resource (xv, 751 pages, [16] pages of plates)
Form of item
Media category
Media MARC source
Media type code
Other physical details
illustrations (some color)
Specific material designation
System control number
  • (OCoLC)762324875
  • CRC1439813833

Library Locations

    • Deakin University Library - Geelong Waurn Ponds CampusBorrow it
      75 Pigdons Road, Waurn Ponds, Victoria, 3216, AU
      -38.195656 144.304955
Processing Feedback ...