The Resource Biocompatible nanomaterials for targeted and controlled delivery of biomacromolecules, Deepak N. Kapoor and Sanju Dhawan

Biocompatible nanomaterials for targeted and controlled delivery of biomacromolecules, Deepak N. Kapoor and Sanju Dhawan

Label
Biocompatible nanomaterials for targeted and controlled delivery of biomacromolecules
Title
Biocompatible nanomaterials for targeted and controlled delivery of biomacromolecules
Statement of responsibility
Deepak N. Kapoor and Sanju Dhawan
Creator
Contributor
Subject
Language
eng
Summary
Nanomaterials are organic or inorganic entities employed for the construction of various nanostructured devices or systems with nanometric dimensions. These nanostructures may include nanoparticles, nanowires, nanotubes, nanocapsules, nanocomposites as well as nanoporous solids. Nanomaterials have gained immense recognition, particularly in biomacromolecular delivery, owing to their capability of controlling the release rate or targeting the therapeutic moieties at molecular, cellular and organ level. Additionally, the problems of conformational and degradation stability associated with biomacromolecules like peptides, proteins, and genes have been addressed successfully by employing these nanomaterials. The degradation products of these biocompatible nanomaterials are non-toxic, non-immunogenic and easily resorbable by the regular physiological processes. The present chapter endeavors to describe the role of nanomaterials in the design, fabrication and development of various nanostructured, biomacromolecular delivery systems and devices. The chapter presents a discussion on various physicochemical properties, preparation techniques and analytical tools for characterizing these systems. The mechanisms of cellular internalization of nanomaterial based targeted systems are also discussed. Taking lead from various successful case studies, the present chapter provides a bird's eye view on the current advances in the field of nanomaterial based biomacromolecular delivery. A brief overview pertaining to the regulatory requirements and commercialization of these systems is also included. Various challenges posed during the development, scale up and large-scale production is also discussed. In a nutshell, besides, providing the salient details about the formulation and applications of biocompatible nanomaterials, the chapter would act as a ready reference for drug delivery scientists, device fabrication engineers and medical researchers working in this area
Member of
Cataloging source
NYMPP
Dewey number
574.1924
Illustrations
illustrations
Index
index present
LC call number
QP801.P64
LC item number
K263 2013
Literary form
non fiction
Nature of contents
  • dictionaries
  • abstracts summaries
  • bibliography
Series statement
Biomedical and nanomedical technologies
Target audience
  • adult
  • specialized
Label
Biocompatible nanomaterials for targeted and controlled delivery of biomacromolecules, Deepak N. Kapoor and Sanju Dhawan
Publication
Note
Title from PDF title page (viewed on May 29, 2013)
Bibliography note
Includes bibliographical references (pages 38-47) and index
http://library.link/vocab/branchCode
  • net
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
  • 1. Nanomaterials: a brief introduction
  • 2. Tissue and blood-material interactions -- 2.1 Tissue response -- 2.2 Blood response -- 2.3 Cellular response
  • 3. Biocompatibility
  • 4. Biodegradation
  • 5. Biocompatible and biodegradable nanomaterials -- 5.1 Organic nanomaterials -- 5.1.1 Natural and modified natural nanomaterials -- 5.1.2 Synthetic polymeric nanomaterials -- 5.2 Stealth nanomaterials -- 5.3 Inorganic nanomaterials -- 5.3.1 Carbon nanotubes (CNTs) -- 5.3.2 Quantum dots (QDs) -- 5.3.3 End-capped mesoporous silica nanoparticles -- 5.4 Metal nanoparticles -- 5.4.1 Gold nanoparticles (Au-Nps) -- 5.4.2 Silver nanoparticles -- 5.5 Magnetic nanoparticles -- 5.6 Nanocomposites, nanofibres and nanowires -- 5.7 Hybrid nanomaterials -- 5.8 Virus-like nanocarriers -- 5.9 Multifunctional nanoparticles
  • 6. Biomacromolecules -- 6.1 Cell penetrating peptides in biomacromolecular delivery -- 6.2 Targeted biomacromolecular delivery
  • 7. Challenges in biomacromolecular delivery
  • 8. Preparation techniques of biocompatible nanostructures -- 8.1 Top-down techniques -- 8.1.1 Dispersion of preformed polymers -- 8.1.2 Polymerization methods -- 8.1.3 Ionic gelation method for hydrophilic polymers -- 8.1.4 Hybrid assemblies -- 8.2 Bottom-up techniques -- 8.3 Scalable methods
  • 9. Characterization and evaluation -- 9.1 Drug-polymer compatibility -- 9.2 Particle size and shape -- 9.3 Zeta potential -- 9.4 Drug release evaluation -- 9.5 Conformational stability -- 9.6 Biocompatibility studies -- 9.7 Pre-clinical evaluation
  • 10. Regulatory perspectives
  • 11. Industrial viability
  • 12. Conclusions -- References
Control code
000058641004
Dimensions
unknown
Extent
1 online resource (47 pages)
File format
multiple file formats
Form of item
online
Isbn
9781606506028
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1115/1.860113
Other physical details
illustrations
Publisher number
860113
http://library.link/vocab/recordID
.b33836048
Reformatting quality
access
Specific material designation
remote
System control number
  • (OCoLC)844954577
  • pebcdda1606506021

Library Locations

    • Deakin University Library - Geelong Waurn Ponds CampusBorrow it
      75 Pigdons Road, Waurn Ponds, Victoria, 3216, AU
      -38.195656 144.304955
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