The Resource Mapping small molecule binding sites with phage display technology, Lee Makowski, (electronic resource)

Mapping small molecule binding sites with phage display technology, Lee Makowski, (electronic resource)

Label
Mapping small molecule binding sites with phage display technology
Title
Mapping small molecule binding sites with phage display technology
Statement of responsibility
Lee Makowski
Creator
Speaker
Subject
Language
eng
Member of
Cataloging source
UkLU-K
Characteristic
representational
Series statement
Chemical biology : the role of chemistry in our fundamental understanding of biology,
Label
Mapping small molecule binding sites with phage display technology, Lee Makowski, (electronic resource)
Publication
Note
  • Animated audio-visual presentation with synchronized narration
  • Title from title frames
http://library.link/vocab/branchCode
  • net
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Configuration of playback channels
monaural
Content category
two-dimensional moving image
Content type code
tdi
Content type MARC source
rdaconent
Contents
Contents: How do you identify the molecular target of a small molecule drug? -- Flexible regions are key players -- P-loop of ATP-binding proteins is an important example -- Can display libraries of flexible peptides on proteins select those that bind to the ligand -- Selection is through an affinity process called biopanning -- Success depends on the diversity of the library -- Diversity depends on how many different peptides are in the library and their relative abundance -- RELIC can be used to calculate the diversity of a library from the sequences of 1̃00 peptides -- Identification of motifs from a population is easy if the motif is very strong -- Taxol-binding peptides were also identified by phage display and those peptides were used to identify the position on tubulin where taxol is bound and to identify Bcl-2 as a taxolbinding protein -- Significant data from a variety of sources argue that the taxol-Bcl-2 interaction is important to the clinical efficacy of taxol
Control code
HST1717_1_2
Dimensions
unknown
Extent
1 online resource (1 streaming video file (39 min.)
File format
one file format
Governing access note
Access restricted to subscribers
Media category
  • video
  • computer
Media MARC source
  • rdamedia
  • rdamedia
Media type code
  • v
  • c
Medium for sound
other
Other physical details
color, sound)
Publisher number
1717
http://library.link/vocab/recordID
.b37237986
Sound
sound
Sound on medium or separate
sound on medium
Specific material designation
  • remote
  • other
System control number
  • HST171712
  • (UkLU-K)AC000393605
System details
  • Mode of access: World Wide Web
  • System requirements: Browser compatibility: updated Mozilla Firefox, Google Chrome, Safari or Internet Explorer 8+. Browser settings: enable JavaScript, enable cookies from the Henry Stewart Talks site. Required Desktop Browser plugins & viewers: Updated Adobe Flash Player & Adobe Acrobat Reader. Mobile device & operating system versions: Android v4.0+, iPhone 4+ (iOS v6.x+), iPad 2+ (iOS v6.x+), BlackBerry OS v7.0+, Windows Phone v6.5.1+
Video recording format
other

Library Locations

    • Deakin University Library - Geelong Waurn Ponds CampusBorrow it
      75 Pigdons Road, Waurn Ponds, Victoria, 3216, AU
      -38.195656 144.304955
Processing Feedback ...