The Resource Noninferiority testing in clinical trials : issues and challenges, Tie-Hua Ng

Noninferiority testing in clinical trials : issues and challenges, Tie-Hua Ng

Label
Noninferiority testing in clinical trials : issues and challenges
Title
Noninferiority testing in clinical trials
Title remainder
issues and challenges
Statement of responsibility
Tie-Hua Ng
Creator
Author
Subject
Genre
Language
eng
Summary
"This book focuses on the rationale of choosing the noninferiority (NI) margin as a small fraction of the therapeutic effect of the active control in a clinical trial. It discusses issues of estimating the effect size based on historical placebo control trials of the active control. The book also covers basic concepts related to NI trials, such as essay sensitivity, constancy assumption, discounting, and preservation. Other topics described include patient populations, three-arm trials, and testing equivalence of three or more groups"--Provided by publisher
Member of
Cataloging source
N$T
Dewey number
615.5072/4
Index
index present
LC call number
R853.C55
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Series statement
Chapman & Hall/CRC biostatistics series
Label
Noninferiority testing in clinical trials : issues and challenges, Tie-Hua Ng
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references and index
http://library.link/vocab/branchCode
  • net
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
1. Introduction -- 2. Choice of noninferiority margin for the mean difference -- 3. Choice of noninferiority margin for the mean ratio and hazard ratio -- 4. Noninferiority Hypotheses with Binary Endpoints -- 5. Two statistical approaches for testing the noninferiority hypothesis -- 6. Switching between superiority and noninferiority -- 7. Multiple historical studies and meta-analysis -- 8. Three treatment groups -- 9. Regulatory guidances -- 10. Intention-to-treat versus per-protocol -- 11. Thrombolytic example -- 12. Issues and challenges
Control code
ocn895661613
Dimensions
unknown
Extent
1 online resource
File format
unknown
Form of item
online
Isbn
9781466561502
Lccn
2014036257
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Quality assurance targets
not applicable
http://library.link/vocab/recordID
.b34212061
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)895661613
  • CRC1466561505

Library Locations

    • Deakin University Library - Geelong Waurn Ponds CampusBorrow it
      75 Pigdons Road, Waurn Ponds, Victoria, 3216, AU
      -38.195656 144.304955
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