The Resource PI3K-mTOR in cancer and cancer therapy, Nandini Dey, Pradip De, Brian Leyland-Jones, editors

PI3K-mTOR in cancer and cancer therapy, Nandini Dey, Pradip De, Brian Leyland-Jones, editors

Label
PI3K-mTOR in cancer and cancer therapy
Title
PI3K-mTOR in cancer and cancer therapy
Statement of responsibility
Nandini Dey, Pradip De, Brian Leyland-Jones, editors
Contributor
Editor
Subject
Language
eng
Summary
In the post human-genome project era, cancer specific genomic maps are redesigning tumor taxonomy by evolving from histopathology to molecular pathology. The success of a cancer drug today is fundamentally based on the success in identifying target genes that control beneficial pathways. The overwhelming power of genomics and proteomics has enlightened researchers about the fact that the PI3K-mTOR pathway is the most commonly up-regulated signal transduction pathway in various cancers, either by virtue of its activation downstream of many cell surface growth factor receptors or by virtue of its collateral and compensatory circuitry with RAS-MAPK pathway. Oncogenic signaling in the majority of solid tumors is sustained via the PI3K-AKT-mTOR pathway. Because of its prominent role in many cancer types, the PI3K-mTOR pathway has become a major therapeutic target. The volume includes two complementary parts which address the problem of etiology and disease progression and is intended to portray the very basic mechanisms of the PI3K-AKT-mTOR signaling pathway's involvement in various facets of the cancer, including stem cell renewal, cell metabolism, angiogenesis, genetic instability, and drug resistance. Significant progress has been made in recent years elucidating the molecular mechanism of cancer cell proliferation, angiogenesis, and drug-resistance in relation to the PI3K-mTOR pathway and this volume provides an in-depth overview of recent developments made in this area
Member of
Cataloging source
N$T
Dewey number
616.99/4
Illustrations
illustrations
Index
index present
LC call number
RC268.4
Literary form
non fiction
Nature of contents
dictionaries
Series statement
Cancer drug discovery and development,
Label
PI3K-mTOR in cancer and cancer therapy, Nandini Dey, Pradip De, Brian Leyland-Jones, editors
Publication
Note
Includes index
Antecedent source
unknown
Bibliography note
Includes bibliographical references at the end of each chapters and index
http://library.link/vocab/branchCode
  • net
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
PI3K-Akt-mTOR Signaling in Cancer and Cancer Therapeutics -- Part 1: PI3K-mTOR Pathway in Cancers -- The mTOR Complexes in Cancer Cell Metabolism -- PI3K-AKT-mTOR Pathway Co-operates with the DNA Damage Repair Pathway: Carcinogenesis in Triple Negative Breast Cancers and Beyond -- The AKT-mTOR Signaling Pathway for Drug Response Prediction and Prognostic Signatures -- Resistance to PI3K Pathway Inhibition -- Part 2: PI3K-mTOR Pathway in Cancer Medicine -- Combination Therapies Targeting the PI3K/AKT/mTOR Pathways -- Phospho-Inositol-3-Kinase Activity and Dysregulation in Pediatric Leukemia and Lymphoma -- HER2 Signaling Network in Advanced Breast Cancer: Opportunities for Combination Therapies -- The PI3K-mTOR Pathway in Prostate Cancer: Biological Significance and Therapeutic Opportunities
Control code
ocn951678372
Dimensions
unknown
Extent
1 online resource (xxiv, 294 pages)
File format
unknown
Form of item
online
Isbn
9783319342092
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other control number
10.1007/978-3-319-34211-5
Other physical details
color illustrations
Quality assurance targets
unknown
http://library.link/vocab/recordID
.b35316895
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)951678372
  • springer3319342096

Library Locations

    • Deakin University Library - Geelong Waurn Ponds CampusBorrow it
      75 Pigdons Road, Waurn Ponds, Victoria, 3216, AU
      -38.195656 144.304955
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