The Resource Streptomyces in nature and medicine : the antibiotic makers, David A. Hopwood

Streptomyces in nature and medicine : the antibiotic makers, David A. Hopwood

Label
Streptomyces in nature and medicine : the antibiotic makers
Title
Streptomyces in nature and medicine
Title remainder
the antibiotic makers
Statement of responsibility
David A. Hopwood
Creator
Subject
Language
eng
Summary
This is an insider's account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes - the actinomycetes - were discovered in the latter part of the nineteenth century, but remained a 'Cinderella' group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic after penicillin to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium.; There follow chapters in which the intricate molecular machinery that adapts the organisms' metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then comes an up-to-the minute account of the use of genetic engineering to make novel, hybrid antibiotics and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic prductivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens
Cataloging source
N$T
Dewey number
579.3/78
Illustrations
  • illustrations
  • plates
Index
index present
LC call number
QR82.S8
LC item number
H57 2007eb
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Label
Streptomyces in nature and medicine : the antibiotic makers, David A. Hopwood
Publication
Antecedent source
unknown
Bibliography note
Includes bibliographical references (pages 229-240) and index
http://library.link/vocab/branchCode
  • net
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Actinomycetes and antibiotics -- Antibiotic discovery and resistance -- Microbial sex -- Towards gene cloning -- From chromosome map to DNA sequence -- Bacteria that develop -- The switch to antibiotic production -- Unnatural natural products -- Functional genomics -- Genomics against tuberculosis and leprosy
Control code
ocn171154211
Dimensions
unknown
Extent
1 online resource (viii, 250 pages, [8] pages of plates)
File format
unknown
Form of item
online
Isbn
9780199722280
Level of compression
unknown
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations (some color)
Quality assurance targets
not applicable
http://library.link/vocab/recordID
.b3603017x
Reformatting quality
unknown
Sound
unknown sound
Specific material designation
remote
System control number
  • (OCoLC)171154211
  • pebcs0199722285

Library Locations

    • Deakin University Library - Geelong Waurn Ponds CampusBorrow it
      75 Pigdons Road, Waurn Ponds, Victoria, 3216, AU
      -38.195656 144.304955
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