The Resource Therapeutic applications of quadruplex nucleic acids, Stephen Neidle

Therapeutic applications of quadruplex nucleic acids, Stephen Neidle

Label
Therapeutic applications of quadruplex nucleic acids
Title
Therapeutic applications of quadruplex nucleic acids
Statement of responsibility
Stephen Neidle
Creator
Subject
Language
eng
Summary
New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in therapeutic application and targeting strategies, until now. Quadruplex Nucleic Acids as Therapeutic Targets will be a vital resource for researchers in biochemistry, molecular biology, chemistry, biotechnology, biophysics, medicine, translational science and pharmacology. This timely publication is the first to offer practical application and direct strategies to meet the needs of emerging research
Cataloging source
OPELS
Dewey number
615.36
Illustrations
illustrations
Index
index present
LC call number
QP625.Q33
LC item number
N45 2012
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
Label
Therapeutic applications of quadruplex nucleic acids, Stephen Neidle
Publication
Bibliography note
Includes bibliographical references and index
http://library.link/vocab/branchCode
  • net
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Contents
Intro -- history and milestones -- Fundamentals of DNA and RNA quadruplex structure and stability -- Quadruplexes as therapeutic targets for telomeres and relationship to telomerase and telomere maintenance -- Genomic DNA and RNA quadruplexes -- involvement in gene expression and potential as therapeutic agents -- Quadruplex targets and human disease -- applicability in cancer and infectious disease, including oncogene targets such as c-myc and c-kit -- Quadruplex ligands -- chemistry and design -- selectivity and assays -- Quadruplex ligands -- basic biology and assays indirect and direct -- Quadruplex ligands -- pharmacology and druggability, ligands in clinical trial and pre-clinical trial development -- Synthetic quadruplexes and drugs -- therapeutic aptamers, including thrombin, STAT3 binding, nucleolin binding -- Future directions and conclusions
Control code
ocn756490841
Dimensions
unknown
Edition
1st ed
Extent
1 online resource (xii, 196 pages)
Form of item
online
Isbn
9780123751393
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
http://library.link/vocab/ext/overdrive/overdriveId
1057475:10578491
http://library.link/vocab/recordID
.b26617869
Specific material designation
remote
System control number
  • (OCoLC)756490841
  • sciencedirect0123751381

Library Locations

    • Deakin University Library - Geelong Waurn Ponds CampusBorrow it
      75 Pigdons Road, Waurn Ponds, Victoria, 3216, AU
      -38.195656 144.304955
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